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KMID : 0882420120830010136
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Korean Journal of Medicine
2012 Volume.83 No. 1 p.136 ~ p.140
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A Case of Hypersensitivity Reaction Induced by Abacavir in an AIDS Patient
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Ko Seong-Joo
Heo Sang-Taek
Kim Jin-Seok
Kim Young-Ree
Kim Jae-Wang
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Abstract
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Abacavir is a nucleoside reverse transcriptase inhibitor that is commonly used in HIV-infected patients. A well-known and potentially life-threatening side effect of abacavir is allergic hypersensitivity reaction. A screening test for the HLA-B*5701 allele is currently used to predict the risk of hypersensitivity reaction to abacavir. This test, however, may be less useful in Korea, because of the low prevalence of HLA-B*5701. A 52-year-old male with HIV infection was referred to our hospital because of suspected side-effects of antiviral agents and lymph node enlargement of the neck. He suffered from a fever, generalized edema, skin rash of the whole body, and difficulty breathing after starting antiviral agents. Suspected as a hypersensitivity reaction resulting from drug side-effects, prescription of abacavir was stopped. The patient subsequently recovered. The presence of the HLA-B*5701 allele was confirmed by polymerase chain reaction-sequencing based typing (PCR-SBT).
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KEYWORD
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Abacavir, HLA-B antigens, Hypersensitivity
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